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Ranking the Biggest Cinderella Runs in the NCAA Men’s Basketball Tournament Since 2000

The “Cinderella story” is the soul of March Madness—those rare, bracket-busting runs where mid-majors like George Mason (2006) or Loyola Chicago (2018) topple blue-blood giants to reach the Final Four. Whether it’s the high-flying “Dunk City” style of FGCU or the legendary scoring of Stephen Curry, these teams prove that a low seed is often just an invitation to make history.

As the 2026 Tournament tips off today, all eyes are on #11 VCU as they prepare to face North Carolina tonight—aiming to recapture the same underdog magic that defined their historic 2011 run.